I have a single core MP5,1 with 4X32gb RAM. It works if you use the Martin lo Open core boot efi. Meaning download Open core at Github.com version 1.01 or 0.98 (there are some versions) Search on Youtube and you find vides explaining how to set it all up. Works from Mojave to Monerey. High Sierra too as long as you boot with Open core. Not Ventura, Sonoma or Seqoia however due to some coding issues as I´ve heard.
It looks like the single core with this config has 256 gb in system info, but off coarse thats not true. But it works fine.