I had done a complete reset of the laptop, installed Windows 10 and ran into this problem, I reloaded all the drivers from the Acer site and it didn’t fix it. It was a BIOS issues - restart the computer and hit F2 when the logo appears to access the BIOS menus, go to Main and the Touchpad setting, it seems to default to “Advanced” and when I selected [Basic] and rebooted it is working again!
I have a tray full of tools for this work - following the instructions in sequence took less than 30 minutes with no problems at all and the phone is now fully functional again. The internal design of the Nexus 5X phone is much better than more modern phones and the battery replacement is relatively simple and easy.
If you use the ifixit heat-pad to remove the battery and gently lever the battery away from the internal glue then the original glue will still be functional.